Purpose: What is the purpose of being here? Why do we wake up everyday and do what we do? Is there a purpose? Can we live without a purpose? Is our purpose for us or for the people around us, do people depending on you literally and figuratively give you purpose? If you're alone what happens?
Relationship: How do we relate to others? Do we choose who we relate ourselves to? Do these relationship matter? Can you relate to a total stranger? Can you relate to a family member? What do you get from a relationship? Does it matter in the long run who we know and who knows us? Relationships preserve who we are, if nobody knew us and what we did then would we really exist.
Life/Death: The two things that we are destined to do. Does anything in between these two events matter? You appear in your local newspaper when these things happen. Joy and happiness versus gloomy and sadness. Both events are looked forward to. Where you are born is not where you will die. The people that were there when you were may not be there when you die. You life accumulates things and people that you have to let go of when you die. One thing you have when you die that you didn't have when you were born is memory, it starts with your first breath and it follows you until you die, the memory of you and your existence.